Drug interactions
Aripiprazole + Indinavir
Severity: Moderate
Aripiprazole and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, one of the two main enzymes that clear aripiprazole, so aripiprazole exposure can rise. This may increase adverse effects such as akathisia, sedation, orthostatic hypotension and extrapyramidal symptoms.
What this interaction means in plain words
Aripiprazole and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4-mediated metabolism of aripiprazole.
What to do
Reduce the aripiprazole dose to about half of the usual dose when a strong CYP3A4 inhibitor is added, per labeling, and return to the usual dose when the inhibitor is stopped. Monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Indinavir?
MediHelp rates the interaction as moderate. Aripiprazole and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4, one of the two main enzymes that clear aripiprazole, so aripiprazole exposure can rise. This may increase adverse effects such as akathisia, sedation, orthostatic hypotension and extrapyramidal symptoms.
How serious is the interaction between Aripiprazole and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the aripiprazole dose to about half of the usual dose when a strong CYP3A4 inhibitor is added, per labeling, and return to the usual dose when the inhibitor is stopped. Monitor for adverse effects.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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