Drug interactions
Aripiprazole + Inotuzumab
Severity: Moderate
Aripiprazole and Inotuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin is associated with QT prolongation, and aripiprazole may contribute a minor additional effect. The combination slightly raises the risk of arrhythmia in patients with other risk factors.
What this interaction means in plain words
Aripiprazole and Inotuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain ECGs and electrolytes at baseline and periodically during treatment. Correct hypokalemia and hypomagnesemia, and reassess the antipsychotic if the QTc lengthens substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Inotuzumab?
MediHelp rates the interaction as moderate. Aripiprazole and Inotuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inotuzumab ozogamicin is associated with QT prolongation, and aripiprazole may contribute a minor additional effect. The combination slightly raises the risk of arrhythmia in patients with other risk factors.
How serious is the interaction between Aripiprazole and Inotuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs and electrolytes at baseline and periodically during treatment. Correct hypokalemia and hypomagnesemia, and reassess the antipsychotic if the QTc lengthens substantially.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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