Drug interactions
Aripiprazole + Isoniazid
Severity: Minor
Aripiprazole and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole is metabolised by CYP3A4 and CYP2D6, and isoniazid may slightly raise its concentrations. Clinical impact is expected to be small compared with strong inhibitors.
What this interaction means in plain words
Aripiprazole and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak inhibition of CYP3A4 by isoniazid reducing aripiprazole clearance.
What to do
No routine dose change is required. Monitor for akathisia, sedation or other aripiprazole adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Isoniazid?
MediHelp rates the interaction as minor. Aripiprazole and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole is metabolised by CYP3A4 and CYP2D6, and isoniazid may slightly raise its concentrations. Clinical impact is expected to be small compared with strong inhibitors.
How serious is the interaction between Aripiprazole and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required. Monitor for akathisia, sedation or other aripiprazole adverse effects.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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