Drug interactions
Aripiprazole + Levodopa inhaled
Severity: Moderate
Aripiprazole and Levodopa inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole's dopamine D2 activity can oppose the effect of inhaled levodopa, which is used for off episodes in Parkinson's disease. The result may be reduced benefit and worsening parkinsonism.
What this interaction means in plain words
Aripiprazole and Levodopa inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid combining where possible, and choose a lower-risk antipsychotic such as quetiapine or clozapine if one is required. Monitor motor control and the response to levodopa.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Levodopa inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Levodopa inhaled?
MediHelp rates the interaction as moderate. Aripiprazole and Levodopa inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole's dopamine D2 activity can oppose the effect of inhaled levodopa, which is used for off episodes in Parkinson's disease. The result may be reduced benefit and worsening parkinsonism.
How serious is the interaction between Aripiprazole and Levodopa inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, and choose a lower-risk antipsychotic such as quetiapine or clozapine if one is required. Monitor motor control and the response to levodopa.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
