Drug interactions
Aripiprazole + Levorphanol
Severity: Moderate
Aripiprazole and Levorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with antipsychotics can produce additive sedation, dizziness, hypotension and respiratory depression. The risk is greatest at initiation and with higher doses.
What this interaction means in plain words
Aripiprazole and Levorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depressant effects.
What to do
Start levorphanol at the lowest effective dose and titrate carefully. Monitor for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Levorphanol?
MediHelp rates the interaction as moderate. Aripiprazole and Levorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids combined with antipsychotics can produce additive sedation, dizziness, hypotension and respiratory depression. The risk is greatest at initiation and with higher doses.
How serious is the interaction between Aripiprazole and Levorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start levorphanol at the lowest effective dose and titrate carefully. Monitor for sedation and respiratory depression.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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