Drug interactions
Aripiprazole + Lofepramine
Severity: Moderate
Aripiprazole and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and orthostatic hypotension, and lofepramine may also raise aripiprazole levels through CYP2D6 inhibition, although this effect is weaker than with other tricyclics. The result may be more drowsiness, dizziness and anticholinergic or cardiac effects.
What this interaction means in plain words
Aripiprazole and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedative and hypotensive effects, with possible minor CYP2D6 inhibition by the tricyclic metabolite.
What to do
Monitor for sedation, orthostatic hypotension and aripiprazole adverse effects, and adjust doses if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Lofepramine?
MediHelp rates the interaction as moderate. Aripiprazole and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and orthostatic hypotension, and lofepramine may also raise aripiprazole levels through CYP2D6 inhibition, although this effect is weaker than with other tricyclics. The result may be more drowsiness, dizziness and anticholinergic or cardiac effects.
How serious is the interaction between Aripiprazole and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and aripiprazole adverse effects, and adjust doses if they occur.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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