Drug interactions
Aripiprazole + Lorcaserin
Severity: Moderate
Aripiprazole and Lorcaserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist and CYP2D6 inhibitor, so it may raise aripiprazole levels and add serotonergic effects. Serotonin syndrome and neuroleptic malignant syndrome are theoretical concerns. Lorcaserin has been withdrawn from many markets.
What this interaction means in plain words
Aripiprazole and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lorcaserin inhibits CYP2D6 and has serotonergic activity that may add to the effects of aripiprazole.
What to do
Monitor for serotonin toxicity, NMS and aripiprazole adverse effects, and reduce the aripiprazole dose if exposure appears increased.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Lorcaserin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Lorcaserin?
MediHelp rates the interaction as moderate. Aripiprazole and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorcaserin is a serotonin 5-HT2C agonist and CYP2D6 inhibitor, so it may raise aripiprazole levels and add serotonergic effects. Serotonin syndrome and neuroleptic malignant syndrome are theoretical concerns. Lorcaserin has been withdrawn from many markets.
How serious is the interaction between Aripiprazole and Lorcaserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity, NMS and aripiprazole adverse effects, and reduce the aripiprazole dose if exposure appears increased.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
