Drug interactions
Aripiprazole + Meclizine
Severity: Minor
Aripiprazole and Meclizine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is a sedating antihistamine with anticholinergic activity and may add to aripiprazole-related drowsiness and dizziness. Meclizine inhibits CYP2D6 weakly, which could modestly raise aripiprazole levels.
What this interaction means in plain words
Aripiprazole and Meclizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Meclizine belongs to Respiratory.
Why it happens
Additive CNS depression and anticholinergic effects, with possible weak CYP2D6 inhibition.
What to do
Counsel about sedation and driving, and monitor for anticholinergic effects in older patients. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Meclizine
Frequently asked questions
Can I take Aripiprazole with Meclizine?
MediHelp rates the interaction as minor. Aripiprazole and Meclizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Meclizine is a sedating antihistamine with anticholinergic activity and may add to aripiprazole-related drowsiness and dizziness. Meclizine inhibits CYP2D6 weakly, which could modestly raise aripiprazole levels.
How serious is the interaction between Aripiprazole and Meclizine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about sedation and driving, and monitor for anticholinergic effects in older patients. No routine dose change is needed.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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