Drug interactions
Aripiprazole + Metformin-sitagliptin
Severity: Minor
Aripiprazole and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole has a relatively low risk of metabolic disturbance, but hyperglycemia and diabetes have been reported with atypical antipsychotics. Glycemic control may be affected in patients on antidiabetic therapy.
What this interaction means in plain words
Aripiprazole and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through possible antipsychotic-related insulin resistance; effect with aripiprazole is small.
What to do
Monitor glucose and HbA1c periodically during aripiprazole treatment. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Aripiprazole and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole has a relatively low risk of metabolic disturbance, but hyperglycemia and diabetes have been reported with atypical antipsychotics. Glycemic control may be affected in patients on antidiabetic therapy.
How serious is the interaction between Aripiprazole and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c periodically during aripiprazole treatment. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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