Drug interactions
Aripiprazole + Metformin
Severity: Moderate
Aripiprazole and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole may raise blood glucose in some patients, which can work against the glucose-lowering effect of metformin. Aripiprazole has a lower metabolic risk than many other atypical antipsychotics, but glycemic control can still worsen.
What this interaction means in plain words
Aripiprazole and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as atypical antipsychotics can impair insulin sensitivity and glucose regulation.
What to do
Monitor fasting glucose and HbA1c after starting or changing aripiprazole. Adjust the antidiabetic regimen if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Metformin
Frequently asked questions
Can I take Aripiprazole with Metformin?
MediHelp rates the interaction as moderate. Aripiprazole and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole may raise blood glucose in some patients, which can work against the glucose-lowering effect of metformin. Aripiprazole has a lower metabolic risk than many other atypical antipsychotics, but glycemic control can still worsen.
How serious is the interaction between Aripiprazole and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting or changing aripiprazole. Adjust the antidiabetic regimen if control deteriorates.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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