Drug interactions
Aripiprazole + Methylenedioxymethamphetamine
Severity: Major
Aripiprazole and Methylenedioxymethamphetamine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a serotonergic stimulant that causes hyperthermia, tachycardia and hypertension, and it is metabolized by CYP2D6. Aripiprazole may add to cardiovascular and thermoregulatory effects, and serotonin toxicity is possible.
What this interaction means in plain words
Aripiprazole and Methylenedioxymethamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Overlapping serotonergic and dopaminergic effects, with possible CYP2D6 interplay; the interaction is not well characterized.
What to do
Advise patients to avoid MDMA, and monitor temperature, heart rate and mental status if exposure occurs. Seek urgent care for hyperthermia, agitation or rigidity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Methylenedioxymethamphetamine?
MediHelp rates the interaction as major. Aripiprazole and Methylenedioxymethamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MDMA is a serotonergic stimulant that causes hyperthermia, tachycardia and hypertension, and it is metabolized by CYP2D6. Aripiprazole may add to cardiovascular and thermoregulatory effects, and serotonin toxicity is possible.
How serious is the interaction between Aripiprazole and Methylenedioxymethamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid MDMA, and monitor temperature, heart rate and mental status if exposure occurs. Seek urgent care for hyperthermia, agitation or rigidity.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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