Drug interactions
Aripiprazole + Methylergonovine
Severity: Minor
Aripiprazole and Methylergonovine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine has serotonergic activity and aripiprazole modulates serotonin and dopamine receptors, so combined use could in theory contribute to serotonin toxicity or neuroleptic malignant syndrome. Clinical reports are scarce and the risk is mainly theoretical.
What this interaction means in plain words
Aripiprazole and Methylergonovine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive serotonergic and dopaminergic receptor effects; the mechanism is not firmly established.
What to do
Counsel patients to report fever, rigidity, agitation, tremor or autonomic instability after starting the combination. Monitor mental status and temperature, especially with repeated methylergonovine dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Methylergonovine?
MediHelp rates the interaction as minor. Aripiprazole and Methylergonovine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methylergonovine has serotonergic activity and aripiprazole modulates serotonin and dopamine receptors, so combined use could in theory contribute to serotonin toxicity or neuroleptic malignant syndrome. Clinical reports are scarce and the risk is mainly theoretical.
How serious is the interaction between Aripiprazole and Methylergonovine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report fever, rigidity, agitation, tremor or autonomic instability after starting the combination. Monitor mental status and temperature, especially with repeated methylergonovine dosing.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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