Drug interactions
Aripiprazole + Metoclopramide intranasal
Severity: Major
Aripiprazole and Metoclopramide intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide blocks dopamine D2 receptors and can cause extrapyramidal symptoms and tardive dyskinesia. Added to aripiprazole, the risk and severity of these effects, including neuroleptic malignant syndrome, may increase.
What this interaction means in plain words
Aripiprazole and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive dopamine D2 receptor antagonism.
What to do
Avoid concurrent use and choose a non-dopamine-blocking antiemetic or prokinetic such as ondansetron where suitable. If given together, monitor for movement disorders, rigidity, and fever.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Metoclopramide intranasal?
MediHelp rates the interaction as major. Aripiprazole and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide blocks dopamine D2 receptors and can cause extrapyramidal symptoms and tardive dyskinesia. Added to aripiprazole, the risk and severity of these effects, including neuroleptic malignant syndrome, may increase.
How serious is the interaction between Aripiprazole and Metoclopramide intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-dopamine-blocking antiemetic or prokinetic such as ondansetron where suitable. If given together, monitor for movement disorders, rigidity, and fever.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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