Drug interactions
Aripiprazole + Miconazole vaginal
Severity: Minor
Aripiprazole and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole inhibits CYP3A4 and could raise aripiprazole exposure, but vaginal use gives low systemic absorption so the effect is likely small. Higher levels could cause more akathisia, sedation or orthostasis.
What this interaction means in plain words
Aripiprazole and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated aripiprazole metabolism by absorbed miconazole.
What to do
No empirical dose change is needed for short vaginal courses. Watch for increased adverse effects such as akathisia or sedation if use is prolonged or repeated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Miconazole vaginal?
MediHelp rates the interaction as minor. Aripiprazole and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miconazole inhibits CYP3A4 and could raise aripiprazole exposure, but vaginal use gives low systemic absorption so the effect is likely small. Higher levels could cause more akathisia, sedation or orthostasis.
How serious is the interaction between Aripiprazole and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed for short vaginal courses. Watch for increased adverse effects such as akathisia or sedation if use is prolonged or repeated.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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