Drug interactions
Aripiprazole + Octreotide
Severity: Moderate
Aripiprazole and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and has been associated with QT prolongation, while aripiprazole has a low but possible effect on QT. Together they may modestly increase arrhythmia risk, especially with other risk factors.
What this interaction means in plain words
Aripiprazole and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Possible additive effects on cardiac repolarization and heart rate.
What to do
Obtain a baseline ECG in patients with cardiac disease or electrolyte disturbance, and correct potassium and magnesium. Monitor the QTc and heart rate during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Octreotide
Frequently asked questions
Can I take Aripiprazole with Octreotide?
MediHelp rates the interaction as moderate. Aripiprazole and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and has been associated with QT prolongation, while aripiprazole has a low but possible effect on QT. Together they may modestly increase arrhythmia risk, especially with other risk factors.
How serious is the interaction between Aripiprazole and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac disease or electrolyte disturbance, and correct potassium and magnesium. Monitor the QTc and heart rate during therapy.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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