Drug interactions
Aripiprazole + Protriptyline
Severity: Moderate
Aripiprazole and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and may impair psychomotor performance when combined. Protriptyline is also partly metabolized by CYP2D6, which aripiprazole depends on, so exposure to either drug may change, though the clinical significance is modest.
What this interaction means in plain words
Aripiprazole and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects, with possible minor competition for CYP2D6 metabolism.
What to do
Monitor for excessive sedation, orthostatic hypotension and anticholinergic effects, and counsel patients about driving. Adjust doses if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Protriptyline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Protriptyline?
MediHelp rates the interaction as moderate. Aripiprazole and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and may impair psychomotor performance when combined. Protriptyline is also partly metabolized by CYP2D6, which aripiprazole depends on, so exposure to either drug may change, though the clinical significance is modest.
How serious is the interaction between Aripiprazole and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, orthostatic hypotension and anticholinergic effects, and counsel patients about driving. Adjust doses if adverse effects emerge.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
