Drug interactions
Aripiprazole + Quazepam
Severity: Moderate
Aripiprazole and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an antipsychotic with a benzodiazepine hypnotic increases drowsiness, dizziness and impaired coordination. Falls and next-day impairment are particularly relevant in older patients.
What this interaction means in plain words
Aripiprazole and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through different receptor mechanisms (GABA-A potentiation and antihistaminic/antiadrenergic effects of aripiprazole).
What to do
Use the lowest effective quinazepam dose and monitor for oversedation and orthostasis. Advise patients to avoid driving and alcohol until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Quazepam?
MediHelp rates the interaction as moderate. Aripiprazole and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an antipsychotic with a benzodiazepine hypnotic increases drowsiness, dizziness and impaired coordination. Falls and next-day impairment are particularly relevant in older patients.
How serious is the interaction between Aripiprazole and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective quinazepam dose and monitor for oversedation and orthostasis. Advise patients to avoid driving and alcohol until response is known.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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