Drug interactions
Aripiprazole + Quinacrine
Severity: Minor
Aripiprazole and Quinacrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6, which is a main pathway for aripiprazole clearance. Aripiprazole levels could rise, increasing adverse effects such as akathisia, sedation and orthostatic hypotension.
What this interaction means in plain words
Aripiprazole and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of CYP2D6 metabolism of aripiprazole.
What to do
Monitor for increased adverse effects when quinacrine is started. Consider lowering the aripiprazole dose if effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Quinacrine?
MediHelp rates the interaction as minor. Aripiprazole and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinacrine may inhibit CYP2D6, which is a main pathway for aripiprazole clearance. Aripiprazole levels could rise, increasing adverse effects such as akathisia, sedation and orthostatic hypotension.
How serious is the interaction between Aripiprazole and Quinacrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased adverse effects when quinacrine is started. Consider lowering the aripiprazole dose if effects occur.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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