Drug interactions
Aripiprazole + Remimazolam
Severity: Moderate
Aripiprazole and Remimazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a short-acting benzodiazepine sedative, and aripiprazole can add to sedation. Together they may increase hypotension, respiratory depression and prolonged sedation.
What this interaction means in plain words
Aripiprazole and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression.
What to do
Titrate remimazolam carefully, with continuous monitoring of oxygen saturation, respiration and blood pressure during and after the procedure. Use lower doses in patients on antipsychotics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Remimazolam
Frequently asked questions
Can I take Aripiprazole with Remimazolam?
MediHelp rates the interaction as moderate. Aripiprazole and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remimazolam is a short-acting benzodiazepine sedative, and aripiprazole can add to sedation. Together they may increase hypotension, respiratory depression and prolonged sedation.
How serious is the interaction between Aripiprazole and Remimazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully, with continuous monitoring of oxygen saturation, respiration and blood pressure during and after the procedure. Use lower doses in patients on antipsychotics.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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