Drug interactions
Aripiprazole + Sumatriptan intranasal
Severity: Moderate
Aripiprazole and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans and serotonergic antipsychotics have been theoretically linked to serotonin syndrome, though reports are rare. Aripiprazole has partial 5-HT1A agonism, and the overall risk appears low.
What this interaction means in plain words
Aripiprazole and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic activity; mechanism is largely theoretical.
What to do
Counsel patients to report agitation, tremor, fever, diarrhea or rigidity after dosing. No routine dose change is needed unless symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Sumatriptan intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Aripiprazole and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans and serotonergic antipsychotics have been theoretically linked to serotonin syndrome, though reports are rare. Aripiprazole has partial 5-HT1A agonism, and the overall risk appears low.
How serious is the interaction between Aripiprazole and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, fever, diarrhea or rigidity after dosing. No routine dose change is needed unless symptoms appear.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
