Drug interactions
Aripiprazole + Yohimbine
Severity: Moderate
Aripiprazole and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole can cause sedation while yohimbine is a stimulant with anxiogenic and sympathomimetic effects, so the two may partly oppose each other. The net clinical effect is unpredictable, and yohimbine may worsen agitation, anxiety, tachycardia or blood pressure in psychiatric patients.
What this interaction means in plain words
Aripiprazole and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects: yohimbine alpha-2 antagonism increases noradrenergic activity, whereas aripiprazole is a sedating partial dopamine agonist.
What to do
Monitor mental state, heart rate and blood pressure if yohimbine is used with aripiprazole. Stop yohimbine if agitation, anxiety or psychotic symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Yohimbine?
MediHelp rates the interaction as moderate. Aripiprazole and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole can cause sedation while yohimbine is a stimulant with anxiogenic and sympathomimetic effects, so the two may partly oppose each other. The net clinical effect is unpredictable, and yohimbine may worsen agitation, anxiety, tachycardia or blood pressure in psychiatric patients.
How serious is the interaction between Aripiprazole and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental state, heart rate and blood pressure if yohimbine is used with aripiprazole. Stop yohimbine if agitation, anxiety or psychotic symptoms worsen.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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