Drug interactions
Artemether + Desipramine
Severity: Moderate
Artemether and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether has been associated with QT prolongation and desipramine can also affect cardiac conduction. Combined use may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Artemether and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT interval prolongation.
What to do
Obtain an ECG and check electrolytes before use, and monitor for palpitations or syncope. Consider alternatives if other risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Artemether with Desipramine?
MediHelp rates the interaction as moderate. Artemether and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether has been associated with QT prolongation and desipramine can also affect cardiac conduction. Combined use may increase the risk of ventricular arrhythmias.
How serious is the interaction between Artemether and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check electrolytes before use, and monitor for palpitations or syncope. Consider alternatives if other risk factors are present.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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