Drug interactions
Desipramine + Disopyramide
Severity: Contraindicated
Desipramine and Disopyramide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval and slow cardiac conduction, and disopyramide also adds anticholinergic effects. The combination increases the risk of torsades de pointes.
What this interaction means in plain words
Desipramine and Disopyramide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desipramine belongs to Central Nervous System; Disopyramide belongs to Cardiovascular.
Why it happens
Additive QT prolongation and sodium channel blockade.
What to do
Avoid the combination and use alternatives. If unavoidable, monitor ECG and electrolytes closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Desipramine
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
- Desipramine + Phenelzine Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Desipramine with Disopyramide?
MediHelp rates the interaction as contraindicated. Desipramine and Disopyramide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval and slow cardiac conduction, and disopyramide also adds anticholinergic effects. The combination increases the risk of torsades de pointes.
How serious is the interaction between Desipramine and Disopyramide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use alternatives. If unavoidable, monitor ECG and electrolytes closely.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Dofetilide, Ibutilide, Isocarboxazid. The full list is on the Desipramine page.
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