Drug interactions
Artemether + Mifepristone
Severity: Major
Artemether and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use may increase the risk of ventricular arrhythmia. Mifepristone's CYP3A4 inhibition may also raise artemether levels.
What this interaction means in plain words
Artemether and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation, with possible increased artemether exposure via CYP3A4 inhibition.
What to do
Use alternative antimalarial or non-QT-prolonging therapy if available. Otherwise obtain an ECG and correct electrolytes before and during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Artemether with Mifepristone?
MediHelp rates the interaction as major. Artemether and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, so combined use may increase the risk of ventricular arrhythmia. Mifepristone's CYP3A4 inhibition may also raise artemether levels.
How serious is the interaction between Artemether and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use alternative antimalarial or non-QT-prolonging therapy if available. Otherwise obtain an ECG and correct electrolytes before and during treatment.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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