Drug interactions
Artemether + Sertraline
Severity: Moderate
Artemether and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether can prolong the QT interval, and sertraline may add a smaller effect. The combined risk of serious arrhythmia is raised, especially when other risk factors are present.
What this interaction means in plain words
Artemether and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Obtain an ECG before treatment in patients with cardiac risk factors and correct electrolyte disturbances. Monitor for palpitations or syncope during the antimalarial course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Artemether with Sertraline?
MediHelp rates the interaction as moderate. Artemether and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether can prolong the QT interval, and sertraline may add a smaller effect. The combined risk of serious arrhythmia is raised, especially when other risk factors are present.
How serious is the interaction between Artemether and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before treatment in patients with cardiac risk factors and correct electrolyte disturbances. Monitor for palpitations or syncope during the antimalarial course.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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