Drug interactions
Artemether / lumefantrine + Buspirone
Severity: Minor
Artemether / lumefantrine and Buspirone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether is a CYP3A4 inducer with short-course use, and lumefantrine also inhibits CYP2D6; the net effect on buspirone is uncertain but exposure may fall. Reduced anxiolytic effect is possible.
What this interaction means in plain words
Artemether / lumefantrine and Buspirone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 induction by artemether increasing buspirone first-pass and systemic metabolism.
What to do
Monitor for reduced anxiolytic response during and shortly after the antimalarial course. Increase buspirone dose only if clinically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Artemether / lumefantrine and Buspirone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Buspirone?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Buspirone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether is a CYP3A4 inducer with short-course use, and lumefantrine also inhibits CYP2D6; the net effect on buspirone is uncertain but exposure may fall. Reduced anxiolytic effect is possible.
How serious is the interaction between Artemether / lumefantrine and Buspirone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced anxiolytic response during and shortly after the antimalarial course. Increase buspirone dose only if clinically needed.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
