Drug interactions
Artemether / lumefantrine + Cilostazol
Severity: Minor
Artemether / lumefantrine and Cilostazol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether has been shown to induce CYP3A4 and lumefantrine is also metabolized by it. Induction could lower cilostazol exposure and reduce its efficacy. Effects are likely modest and temporary during a short antimalarial course.
What this interaction means in plain words
Artemether / lumefantrine and Cilostazol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Artemether-mediated CYP3A4 induction may increase cilostazol metabolism.
What to do
No dose change is usually needed for a short course; monitor for reduced claudication benefit if used for longer.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cilostazol
Frequently asked questions
Can I take Artemether / lumefantrine with Cilostazol?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Cilostazol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether has been shown to induce CYP3A4 and lumefantrine is also metabolized by it. Induction could lower cilostazol exposure and reduce its efficacy. Effects are likely modest and temporary during a short antimalarial course.
How serious is the interaction between Artemether / lumefantrine and Cilostazol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed for a short course; monitor for reduced claudication benefit if used for longer.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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