Drug interactions
Artemether / lumefantrine + Clopidogrel
Severity: Minor
Artemether / lumefantrine and Clopidogrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether is a weak CYP3A4 inducer and could slightly increase conversion of clopidogrel to its active metabolite. The expected effect on antiplatelet activity is small and short-lived due to the brief antimalarial course.
What this interaction means in plain words
Artemether / lumefantrine and Clopidogrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction may increase clopidogrel bioactivation.
What to do
No dose change is generally needed. Be aware of possible bleeding if the patient has other risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clopidogrel
Frequently asked questions
Can I take Artemether / lumefantrine with Clopidogrel?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Clopidogrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether is a weak CYP3A4 inducer and could slightly increase conversion of clopidogrel to its active metabolite. The expected effect on antiplatelet activity is small and short-lived due to the brief antimalarial course.
How serious is the interaction between Artemether / lumefantrine and Clopidogrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Be aware of possible bleeding if the patient has other risk factors.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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