Drug reference
dronedarone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Arrhythmia)
Mechanism of action
Blocks sodium channels, blocks beta1-adrenergic site, and alters adenyl cyclase generation (ie, negative inotropic effects); blocks potassium channels (eg, hERG) and therefore prolongs cardiac repolarization
Common side effects
- Asthenia
- Nausea
- QTc prolongation
- Early increase in SCr of >10%
- Abdominal pain
- Diarrhea
Boxed warnings
- Increased risk of death, stroke, and heart failure in patients with decompensated HF or permanent AF Heart failure Symptomatic HF with recent decompensation requiring hospitalization NYHA class IV HF Referral to specialized HF clinic ANDROMEDA study showed mortality increased 2-fold in patients with severe HF requiring hospitalization or those referred to HF clinic for worsening symptoms Permanent atrial fibrillation In patients with permanent AF, risk of death or stroke (particularly in the first 2 weeks of therapy) and hospitalization for HF is doubled; contraindica…
Contraindications
- Permanent AF in patients in whom normal sinus rhythm cannot be restored Symptomatic HF with recent decompensation requiring hospitalization, or symptoms of NYHA class IV HF due to doubled risk of death Concomitant strong CYP3A4 inhibitors (eg, grapefruit juice, itraconazole, clarithromycin, e…
- Coadministration with drugs that prolong QT interval may cause torsade de Pointes-type ventricular tachycardia (eg, phenothiazine, TCAs, macrolide antibiotics, class I and III antiarrhythmic agents [amiodarone, flecainide, propafenone, quinidine, disopyramide, dofetilide, sotalol]) Liver toxicit…
Known interactions (78)
- amiodarone + dronedarone Contraindicated
- azithromycin + dronedarone Contraindicated
- citalopram + dronedarone Contraindicated
- donepezil + dronedarone Contraindicated
- dronedarone + erythromycin Contraindicated
- dronedarone + flibanserin Contraindicated
- dronedarone + fluconazole Contraindicated
- dronedarone + imipramine Contraindicated
- dronedarone + itraconazole Contraindicated
- dronedarone + ketoconazole Contraindicated
- dronedarone + memantine-donepezil Contraindicated
- dronedarone + nilotinib Contraindicated
- dronedarone + nortriptyline Contraindicated
- dronedarone + pimozide Contraindicated
- dronedarone + posaconazole Contraindicated
- dronedarone + propafenone Contraindicated
- dronedarone + quinidine Contraindicated
- dronedarone + quinine Contraindicated
- dronedarone + sotalol Contraindicated
- dronedarone + thioridazine Contraindicated
- dronedarone + voriconazole Contraindicated
- dronedarone + ziprasidone Contraindicated
- alfuzosin + dronedarone Major
- amisulpride + dronedarone Major
- anagrelide + dronedarone Major
- aprepitant + dronedarone Major
- aripiprazole + dronedarone Major
- asenapine + dronedarone Major
- buprenorphine + dronedarone Major
- ciprofloxacin + dronedarone Major
- clomipramine + dronedarone Major
- clozapine + dronedarone Major
- colchicine + dronedarone Major
- crizotinib + dronedarone Major
- cyclosporin + dronedarone Major
- dabigatran + dronedarone Major
- dasatinib + dronedarone Major
- degarelix + dronedarone Major
- desflurane + dronedarone Major
- dronedarone + efavirenz Major
- dronedarone + ergotamine Major
- dronedarone + escitalopram Major
- dronedarone + everolimus Major
- dronedarone + fingolimod Major
- dronedarone + fluvoxamine Major
- dronedarone + gemifloxacin Major
- dronedarone + goserelin Major
- dronedarone + granisetron Major
- dronedarone + hydroxyzine Major
- dronedarone + indapamide Major
Related conditions
Frequently asked questions
What drug class is dronedarone?
dronedarone belongs to: Cardiovascular.
How does dronedarone work?
Blocks sodium channels, blocks beta1-adrenergic site, and alters adenyl cyclase generation (ie, negative inotropic effects); blocks potassium channels (eg, hERG) and therefore prolongs cardiac repolarization
What are the common side effects of dronedarone?
Asthenia, Nausea, QTc prolongation, Early increase in SCr of >10%, Abdominal pain, Diarrhea
Which drugs interact with dronedarone?
amiodarone, azithromycin, citalopram, donepezil, erythromycin, flibanserin, fluconazole, imipramine, itraconazole, ketoconazole, memantine-donepezil, nilotinib, nortriptyline, pimozide, posaconazole
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