Drug interactions
Arsenic trioxide + Dronedarone
Severity: Contraindicated
Arsenic trioxide and Dronedarone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide markedly prolongs the QT interval and has caused torsades de pointes. Adding dronedarone, which also prolongs QT, increases that risk.
What this interaction means in plain words
Arsenic trioxide and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Dronedarone belongs to Cardiovascular.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Do not combine; select a non-QT-prolonging alternative to dronedarone during arsenic trioxide therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Chloroquine + Dronedarone Contraindicated
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
- Arsenic trioxide + Hydroxychloroquine Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Dronedarone?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide markedly prolongs the QT interval and has caused torsades de pointes. Adding dronedarone, which also prolongs QT, increases that risk.
How serious is the interaction between Arsenic trioxide and Dronedarone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select a non-QT-prolonging alternative to dronedarone during arsenic trioxide therapy.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Artemether / lumefantrine. The full list is on the Dronedarone page.
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