Drug interactions
Artemether / lumefantrine + Fluticasone-vilanterol
Severity: Moderate
Artemether / lumefantrine and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine can prolong the QT interval, and vilanterol may further affect cardiac repolarization and lower potassium. The combination raises the possibility of serious ventricular arrhythmia.
What this interaction means in plain words
Artemether / lumefantrine and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta2-agonist-induced hypokalemia and tachycardia.
What to do
Check ECG and electrolytes when feasible, especially in patients with cardiac risk factors. Advise patients to report palpitations or fainting during the antimalarial course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Artemether / lumefantrine with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether/lumefantrine can prolong the QT interval, and vilanterol may further affect cardiac repolarization and lower potassium. The combination raises the possibility of serious ventricular arrhythmia.
How serious is the interaction between Artemether / lumefantrine and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes when feasible, especially in patients with cardiac risk factors. Advise patients to report palpitations or fainting during the antimalarial course.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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