Drug interactions
Amitriptyline + Fluticasone-vilanterol
Severity: Major
Amitriptyline and Fluticasone-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline can potentiate the cardiovascular effects of vilanterol, producing tachycardia, arrhythmia and blood pressure changes, and it also prolongs the QT interval. The product label advises extreme caution with tricyclic antidepressants.
What this interaction means in plain words
Amitriptyline and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Tricyclic noradrenaline reuptake inhibition and QT prolongation add to beta-2 agonist cardiac stimulation.
What to do
Monitor heart rate, blood pressure and ECG, especially at the start of treatment and in patients with cardiac disease. Correct electrolytes and consider alternative therapy if arrhythmia emerges.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Amitriptyline and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amitriptyline can potentiate the cardiovascular effects of vilanterol, producing tachycardia, arrhythmia and blood pressure changes, and it also prolongs the QT interval. The product label advises extreme caution with tricyclic antidepressants.
How serious is the interaction between Amitriptyline and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, especially at the start of treatment and in patients with cardiac disease. Correct electrolytes and consider alternative therapy if arrhythmia emerges.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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