Drug interactions
Amiodarone + Fluticasone-vilanterol
Severity: Major
Amiodarone and Fluticasone-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone markedly prolongs the QT interval, and vilanterol may add tachycardia and hypokalemia. This raises the risk of torsades de pointes and other ventricular arrhythmias.
What this interaction means in plain words
Amiodarone and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta-2 agonist sympathetic stimulation and hypokalemia.
What to do
Monitor ECG, potassium and magnesium, and correct deficits. Use the combination only if needed and review it if QTc increases or arrhythmia symptoms develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Amiodarone and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone markedly prolongs the QT interval, and vilanterol may add tachycardia and hypokalemia. This raises the risk of torsades de pointes and other ventricular arrhythmias.
How serious is the interaction between Amiodarone and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium, and correct deficits. Use the combination only if needed and review it if QTc increases or arrhythmia symptoms develop.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amisulpride, Amitriptyline. The full list is on the Fluticasone-vilanterol page.
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