Drug interactions
Artemether / lumefantrine + Imatinib
Severity: Minor
Artemether / lumefantrine and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether can weakly induce CYP3A4 and may modestly lower imatinib concentrations. The clinical effect is probably small for a short antimalarial course. Lumefantrine and imatinib may both affect QT.
What this interaction means in plain words
Artemether / lumefantrine and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction by artemether may increase imatinib clearance.
What to do
Short courses usually need no dose change. Monitor the imatinib response and ECG if QT risk factors exist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Artemether / lumefantrine with Imatinib?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether can weakly induce CYP3A4 and may modestly lower imatinib concentrations. The clinical effect is probably small for a short antimalarial course. Lumefantrine and imatinib may both affect QT.
How serious is the interaction between Artemether / lumefantrine and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Short courses usually need no dose change. Monitor the imatinib response and ECG if QT risk factors exist.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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