Drug interactions
Imatinib + Lomitapide
Severity: Contraindicated
Imatinib and Lomitapide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and can substantially increase lomitapide exposure. This raises the risk of hepatotoxicity and gastrointestinal adverse effects. Lomitapide labeling contraindicates moderate and strong CYP3A4 inhibitors.
What this interaction means in plain words
Imatinib and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Imatinib belongs to Oncology; Lomitapide belongs to Cardiovascular.
Why it happens
Imatinib inhibits CYP3A4, the main pathway of lomitapide metabolism, increasing its plasma concentrations.
What to do
Do not coadminister. Use an alternative lipid-lowering strategy while imatinib is required, or interrupt lomitapide if imatinib is unavoidable and follow labeling.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Imatinib
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
- Bosutinib + Imatinib Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Imatinib with Lomitapide?
MediHelp rates the interaction as contraindicated. Imatinib and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Imatinib inhibits CYP3A4 and can substantially increase lomitapide exposure. This raises the risk of hepatotoxicity and gastrointestinal adverse effects. Lomitapide labeling contraindicates moderate and strong CYP3A4 inhibitors.
How serious is the interaction between Imatinib and Lomitapide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Use an alternative lipid-lowering strategy while imatinib is required, or interrupt lomitapide if imatinib is unavoidable and follow labeling.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lonafarnib, Amobarbital, Apalutamide. The full list is on the Imatinib page.
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