Drug interactions
Imatinib + Lonafarnib
Severity: Contraindicated
Imatinib and Lonafarnib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A4 substrate, and imatinib inhibits CYP3A4. Increased lonafarnib exposure can worsen gastrointestinal toxicity, hepatic effects, and QT-related risks. Labeling contraindicates strong or moderate CYP3A inhibitors.
What this interaction means in plain words
Imatinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Imatinib belongs to Oncology; Lonafarnib belongs to Miscellaneous.
Why it happens
Imatinib inhibits CYP3A4 metabolism of lonafarnib, raising its systemic exposure.
What to do
Avoid the combination. If a CYP3A inhibitor is essential, follow labeling for temporary lonafarnib dose reduction and monitor for toxicity.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
- Bosutinib + Imatinib Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Imatinib with Lonafarnib?
MediHelp rates the interaction as contraindicated. Imatinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and imatinib inhibits CYP3A4. Increased lonafarnib exposure can worsen gastrointestinal toxicity, hepatic effects, and QT-related risks. Labeling contraindicates strong or moderate CYP3A inhibitors.
How serious is the interaction between Imatinib and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If a CYP3A inhibitor is essential, follow labeling for temporary lonafarnib dose reduction and monitor for toxicity.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Amobarbital, Apalutamide. The full list is on the Imatinib page.
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