Drug interactions
Artemether / lumefantrine + Ipratropium-salbutamol
Severity: Moderate
Artemether / lumefantrine and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine can prolong the QT interval, and salbutamol may add to arrhythmia risk through tachycardia and hypokalemia. The risk is higher with high-dose beta-agonist use or electrolyte disturbance.
What this interaction means in plain words
Artemether / lumefantrine and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with salbutamol-induced hypokalemia.
What to do
Correct electrolyte disturbances and consider an ECG in patients with cardiac risk factors. Avoid frequent high-dose salbutamol during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Frequently asked questions
Can I take Artemether / lumefantrine with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether/lumefantrine can prolong the QT interval, and salbutamol may add to arrhythmia risk through tachycardia and hypokalemia. The risk is higher with high-dose beta-agonist use or electrolyte disturbance.
How serious is the interaction between Artemether / lumefantrine and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolyte disturbances and consider an ECG in patients with cardiac risk factors. Avoid frequent high-dose salbutamol during treatment.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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