Drug interactions
Artemether / lumefantrine + Memantine-donepezil
Severity: Major
Artemether / lumefantrine and Memantine-donepezil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine and artemether can prolong the QT interval, and donepezil adds to this effect. The combination may increase the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Artemether / lumefantrine and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation.
What to do
Avoid if possible or temporarily withhold donepezil during treatment. If used together, obtain an ECG and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Frequently asked questions
Can I take Artemether / lumefantrine with Memantine-donepezil?
MediHelp rates the interaction as major. Artemether / lumefantrine and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lumefantrine and artemether can prolong the QT interval, and donepezil adds to this effect. The combination may increase the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Artemether / lumefantrine and Memantine-donepezil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or temporarily withhold donepezil during treatment. If used together, obtain an ECG and correct electrolytes.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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