Drug interactions
Artemether / lumefantrine + Nebivolol
Severity: Moderate
Artemether / lumefantrine and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6, which is the main metabolic route of nebivolol, so nebivolol exposure may rise with bradycardia and hypotension. Both artemether/lumefantrine and beta-blocker effects on the heart may also matter because lumefantrine prolongs the QT interval.
What this interaction means in plain words
Artemether / lumefantrine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated nebivolol metabolism by lumefantrine.
What to do
Monitor heart rate and blood pressure during the antimalarial course and reduce the nebivolol dose if bradycardia or hypotension appears. Check ECG if other QT-prolonging risks exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Artemether / lumefantrine with Nebivolol?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine inhibits CYP2D6, which is the main metabolic route of nebivolol, so nebivolol exposure may rise with bradycardia and hypotension. Both artemether/lumefantrine and beta-blocker effects on the heart may also matter because lumefantrine prolongs the QT interval.
How serious is the interaction between Artemether / lumefantrine and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure during the antimalarial course and reduce the nebivolol dose if bradycardia or hypotension appears. Check ECG if other QT-prolonging risks exist.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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