Drug interactions
Artemether / lumefantrine + Nicardipine
Severity: Minor
Artemether / lumefantrine and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether may induce CYP3A4 on repeated dosing, which could lower nicardipine concentrations. This may reduce blood pressure or angina control during the antimalarial course.
What this interaction means in plain words
Artemether / lumefantrine and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 induction by artemether increases nicardipine metabolism.
What to do
Monitor blood pressure during the 3-day course and for a few days afterwards. Adjust nicardipine only if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Artemether / lumefantrine with Nicardipine?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether may induce CYP3A4 on repeated dosing, which could lower nicardipine concentrations. This may reduce blood pressure or angina control during the antimalarial course.
How serious is the interaction between Artemether / lumefantrine and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during the 3-day course and for a few days afterwards. Adjust nicardipine only if control is lost.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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