Drug interactions
Artemether / lumefantrine + Nilutamide
Severity: Moderate
Artemether / lumefantrine and Nilutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilutamide is reported to inhibit CYP enzymes and could raise artemether and lumefantrine exposure. Lumefantrine can prolong the QT interval, so higher levels may be relevant.
What this interaction means in plain words
Artemether / lumefantrine and Nilutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nilutamide may inhibit CYP3A4-mediated metabolism of artemether and lumefantrine.
What to do
Consider ECG monitoring if the combination is needed and correct electrolytes. Watch for QT-related symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilutamide
Frequently asked questions
Can I take Artemether / lumefantrine with Nilutamide?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Nilutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilutamide is reported to inhibit CYP enzymes and could raise artemether and lumefantrine exposure. Lumefantrine can prolong the QT interval, so higher levels may be relevant.
How serious is the interaction between Artemether / lumefantrine and Nilutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider ECG monitoring if the combination is needed and correct electrolytes. Watch for QT-related symptoms.
What other medicines interact with Nilutamide?
MediHelp also lists interactions of Nilutamide with, for example, Dihydroergotamine intranasal, Mavacamten, Erythromycin base. The full list is on the Nilutamide page.
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