Drug interactions
Dihydroergotamine intranasal + Nilutamide
Severity: Major
Dihydroergotamine intranasal and Nilutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilutamide inhibits CYP3A4 in vitro and might increase dihydroergotamine levels. Excess dihydroergotamine can cause severe vasospasm and ischemia, though the clinical effect of nilutamide is not well documented.
What this interaction means in plain words
Dihydroergotamine intranasal and Nilutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Possible CYP3A4 inhibition by nilutamide may reduce dihydroergotamine clearance.
What to do
Avoid the combination and choose another migraine therapy. If unavoidable, monitor for peripheral ischemia, numbness or chest pain.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilutamide
- Mavacamten + Nilutamide Major
- Artemether / lumefantrine + Nilutamide Moderate
- Erythromycin base + Nilutamide Moderate
- Erythromycin ethylsuccinate + Nilutamide Moderate
- Erythromycin lactobionate + Nilutamide Moderate
- Erythromycin stearate + Nilutamide Moderate
Frequently asked questions
Can I take Dihydroergotamine intranasal with Nilutamide?
MediHelp rates the interaction as major. Dihydroergotamine intranasal and Nilutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilutamide inhibits CYP3A4 in vitro and might increase dihydroergotamine levels. Excess dihydroergotamine can cause severe vasospasm and ischemia, though the clinical effect of nilutamide is not well documented.
How serious is the interaction between Dihydroergotamine intranasal and Nilutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another migraine therapy. If unavoidable, monitor for peripheral ischemia, numbness or chest pain.
What other medicines interact with Nilutamide?
MediHelp also lists interactions of Nilutamide with, for example, Mavacamten, Artemether / lumefantrine, Erythromycin base. The full list is on the Nilutamide page.
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