Drug interactions
Erythromycin ethylsuccinate + Nilutamide
Severity: Moderate
Erythromycin ethylsuccinate and Nilutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilutamide may inhibit CYP3A4, which could raise erythromycin levels, though evidence is limited. Higher exposure may increase QT prolongation and gastrointestinal effects.
What this interaction means in plain words
Erythromycin ethylsuccinate and Nilutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP3A4 inhibition by nilutamide reduces erythromycin metabolism.
What to do
Monitor for QT prolongation and gastrointestinal adverse effects, and avoid other QT-prolonging drugs. Consider a different antibiotic if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilutamide
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Nilutamide?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Nilutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilutamide may inhibit CYP3A4, which could raise erythromycin levels, though evidence is limited. Higher exposure may increase QT prolongation and gastrointestinal effects.
How serious is the interaction between Erythromycin ethylsuccinate and Nilutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for QT prolongation and gastrointestinal adverse effects, and avoid other QT-prolonging drugs. Consider a different antibiotic if risk factors are present.
What other medicines interact with Nilutamide?
MediHelp also lists interactions of Nilutamide with, for example, Dihydroergotamine intranasal, Mavacamten, Artemether / lumefantrine. The full list is on the Nilutamide page.
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