Drug interactions
Artemether / lumefantrine + Nimodipine
Severity: Minor
Artemether / lumefantrine and Nimodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether can weakly induce CYP3A4 with repeated dosing, which may slightly lower nimodipine concentrations. The effect is expected to be small and short-lived given the brief antimalarial course.
What this interaction means in plain words
Artemether / lumefantrine and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction by artemether increases nimodipine metabolism.
What to do
No routine adjustment is needed. Monitor blood pressure response if nimodipine is used during and shortly after the antimalarial course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Artemether / lumefantrine with Nimodipine?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether can weakly induce CYP3A4 with repeated dosing, which may slightly lower nimodipine concentrations. The effect is expected to be small and short-lived given the brief antimalarial course.
How serious is the interaction between Artemether / lumefantrine and Nimodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor blood pressure response if nimodipine is used during and shortly after the antimalarial course.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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