Drug interactions
Darunavir + Nimodipine
Severity: Major
Darunavir and Nimodipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, especially when boosted with ritonavir or cobicistat, inhibits CYP3A4 and can raise nimodipine exposure. Hypotension, flushing and edema may result.
What this interaction means in plain words
Darunavir and Nimodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Nimodipine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by darunavir and its pharmacokinetic booster reduces nimodipine metabolism.
What to do
Monitor blood pressure closely and start with a lower nimodipine dose. Consider an alternative if marked hypotension occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Duvelisib + Nimodipine Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Nimodipine?
MediHelp rates the interaction as major. Darunavir and Nimodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, especially when boosted with ritonavir or cobicistat, inhibits CYP3A4 and can raise nimodipine exposure. Hypotension, flushing and edema may result.
How serious is the interaction between Darunavir and Nimodipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and start with a lower nimodipine dose. Consider an alternative if marked hypotension occurs.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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