Drug interactions
Ceritinib + Nimodipine
Severity: Major
Ceritinib and Nimodipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a strong CYP3A4 inhibitor, and nimodipine undergoes extensive CYP3A4 first-pass metabolism. Nimodipine exposure can increase markedly, causing severe hypotension, bradycardia or flushing.
What this interaction means in plain words
Ceritinib and Nimodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Nimodipine belongs to Cardiovascular.
Why it happens
Ceritinib inhibits CYP3A4, reducing presystemic and systemic clearance of nimodipine.
What to do
Avoid the combination if possible. If necessary, monitor blood pressure and heart rate closely and reduce the nimodipine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
- Duvelisib + Nimodipine Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Nimodipine?
MediHelp rates the interaction as major. Ceritinib and Nimodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib is a strong CYP3A4 inhibitor, and nimodipine undergoes extensive CYP3A4 first-pass metabolism. Nimodipine exposure can increase markedly, causing severe hypotension, bradycardia or flushing.
How serious is the interaction between Ceritinib and Nimodipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, monitor blood pressure and heart rate closely and reduce the nimodipine dose.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Clarithromycin. The full list is on the Nimodipine page.
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