Drug interactions
Artemether / lumefantrine + Umeclidinium-vilanterol
Severity: Moderate
Artemether / lumefantrine and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine can prolong the QTc interval. Vilanterol may add to arrhythmic risk through adrenergic stimulation and potassium lowering.
What this interaction means in plain words
Artemether / lumefantrine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Check ECG and electrolytes if other QT risk factors are present. Correct hypokalemia and hypomagnesemia before treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Artemether / lumefantrine with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether/lumefantrine can prolong the QTc interval. Vilanterol may add to arrhythmic risk through adrenergic stimulation and potassium lowering.
How serious is the interaction between Artemether / lumefantrine and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes if other QT risk factors are present. Correct hypokalemia and hypomagnesemia before treatment.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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