Drug interactions
Artesunate + Deferasirox
Severity: Minor
Artesunate and Deferasirox: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artesunate is converted to its active metabolite dihydroartemisinin, which is cleared by UGT enzymes. Deferasirox may inhibit UGT and raise dihydroartemisinin exposure, potentially increasing adverse effects.
What this interaction means in plain words
Artesunate and Deferasirox have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Artesunate belongs to Anti Parasitic; Deferasirox belongs to Miscellaneous.
Why it happens
Possible UGT inhibition by deferasirox reducing glucuronidation of dihydroartemisinin.
What to do
No routine dose change is needed. Monitor for artesunate adverse effects such as hemolysis and hepatic changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deferasirox
Other interactions of Artesunate
- Artesunate + Rifampicin Major
- Artesunate + Carbamazepine Moderate
- Artesunate + Eltrombopag Moderate
- Artesunate + Imatinib Moderate
- Artesunate + Nevirapine Moderate
- Artesunate + Phenytoin Moderate
Frequently asked questions
Can I take Artesunate with Deferasirox?
MediHelp rates the interaction as minor. Artesunate and Deferasirox have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artesunate is converted to its active metabolite dihydroartemisinin, which is cleared by UGT enzymes. Deferasirox may inhibit UGT and raise dihydroartemisinin exposure, potentially increasing adverse effects.
How serious is the interaction between Artesunate and Deferasirox?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for artesunate adverse effects such as hemolysis and hepatic changes.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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