Drug interactions
Artesunate + Nevirapine
Severity: Moderate
Artesunate and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce exposure to dihydroartemisinin, the active metabolite of artesunate, by inducing metabolic enzymes. This may reduce antimalarial efficacy.
What this interaction means in plain words
Artesunate and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Artesunate belongs to Anti Parasitic; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP enzymes and UGT-mediated clearance, lowering active artesunate metabolite exposure.
What to do
Use the full recommended artesunate course and monitor parasitological and clinical response. Consider follow-up testing for recrudescence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Artesunate
- Artesunate + Rifampicin Major
- Artesunate + Carbamazepine Moderate
- Artesunate + Eltrombopag Moderate
- Artesunate + Imatinib Moderate
- Artesunate + Phenytoin Moderate
- Artesunate + Regorafenib Moderate
Frequently asked questions
Can I take Artesunate with Nevirapine?
MediHelp rates the interaction as moderate. Artesunate and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce exposure to dihydroartemisinin, the active metabolite of artesunate, by inducing metabolic enzymes. This may reduce antimalarial efficacy.
How serious is the interaction between Artesunate and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the full recommended artesunate course and monitor parasitological and clinical response. Consider follow-up testing for recrudescence.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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