Drug interactions
Asenapine + Clonazepam
Severity: Moderate
Asenapine and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and together they can produce greater drowsiness, dizziness and impaired psychomotor performance. Orthostatic hypotension and syncope may also be more likely.
What this interaction means in plain words
Asenapine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Clonazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and asenapine's antihistaminic and antiadrenergic activity.
What to do
Monitor for sedation and blood pressure changes and use the lowest effective doses. Advise patients to rise slowly and avoid driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Clonazepam?
MediHelp rates the interaction as moderate. Asenapine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and together they can produce greater drowsiness, dizziness and impaired psychomotor performance. Orthostatic hypotension and syncope may also be more likely.
How serious is the interaction between Asenapine and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and blood pressure changes and use the lowest effective doses. Advise patients to rise slowly and avoid driving until tolerance is established.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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